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Studies looking at curcumins effects on cholesterol and other lipids have had inconsistent results.
An Iranian study in in 2013 found that curcumin reduced triglycerides, while a Taiwanese study in 2014 found that curcumin significantly reduced LDL (bad) cholesterol and triglycerides in people with metabolic syndrome.
No word on whether it works on politicians' speeches (hah! It's been shown to alleviate joint pain, and can even help with heartburn and indigestion.
Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival.Inhibition of dextran sulfate sodium (DSS)-induced colitis by curcumin in mice has been associated with a downregulation of the expression of p38-MAPK and pro-inflammatory cytokine TNF-α and a reduction of myeloperoxidase (MPO) activity, a marker of neutrophil infiltration in intestinal mucosa.Curcumin has also been shown to improve colitis by preventing STAT3 activation and STAT3-dependent induction of cell proliferation in mouse colon.Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, and genes involved in cell proliferation, adhesion, survival, and differentiation.
The anti-inflammatory effects of curcumin result from its ability to inhibit the NF-κB pathway, as well as other pro-inflammatory pathways like the mitogen-activated protein kinase (MAPK)- and the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT)-dependent signaling pathways.
Nutritionists, functional medicine GPs and physiotherapists commonly use curcumin for its anti-inflammatory qualities.